“ ATEM’s technology directly images vitrified biological macromolecules in single-particle experiments at high resolution. “Subsequently, reconstructed coulomb potential maps then allow the precise modeling of 3D atomic coordinates that elucidate the target structure.
This leads to the identification of novel distinct binding sites and significantly improves the discovery of drug candidates.” Fast turnaround timesĭue to the minimal amount of samples needed, fast turnaround times and statistical certainty, cryo-EM will also support the analysis of adeno-associated virus (AAV) vector-based gene therapies, as well as novel mRNA and plasmid-based drugs, making it a powerful orthogonal tool to support both quality control and R&D efforts, said the companies. Massachusetts General Hospital offers parking for patients and visitors at the Fruit Street, Parkman Street, Yawkey Center and Charles River Plaza garages. “Cryo-EM will expand the portfolio of drug targets that we can generate a 3D understanding of, enhance our knowledge of how to modulate these targets and enable computational drug design for more of our client projects. “ATEM’s cryo-EM expertise is a perfect complement to our established x-ray crystallography platform,” said Grant Wishart, director CADD & structural biology, discovery, at Charles River.
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